本會學術會員 葉奕均 及團隊研究成果獲 2026 International Society for Therapeutic Ultrasound (ISTU) Annual Symposium 接受，以壁報（Poster）形式進行現場發表，展現臺灣在治療性超音波領域之研究實力。
本次國際研討會於 2026 年 6 月 14 日至 19 日 假挪威特隆赫姆（Trondheim, Norway）舉行，為治療性超音波領域的重要國際學術盛會，匯聚全球專家學者共同交流最新研究成果。
葉奕均學術會員及團隊發表之研究題目為 「Low-Intensity Focused Ultrasound Suppresses Acute Seizures through Inhibi on of Calcium Surges and Network Excitability」，為鼓勵會員積極參與國際學術交流、提升臺灣治療性超音波研究能見度，本會提供國際會議壁報發表補助，支持會員將研究成果帶向國際舞臺。
本會謹向葉奕均學術會員及研究團隊表達誠摯祝賀，期盼未來持續精進研究成果，深化國際學術合作，為治療性超音波之臨床應用與科技發展貢獻更多力量。
Abstract Title:
Low-Intensity Focused Ultrasound Suppresses Acute Seizures through Inhibi on of Calcium
All Authors:
Yi-Chun Yeh, National Taiwan University (Primary Presenter)
Chen-Syuan Huang, National Taiwan University
PO-CHUN CHU, National Taiwan University
Hao-Li Liu, National Taiwan University
Preferred Presenta on Type: Poster
Preferred Par cipa on Type: In-person
Abstract Topic: Brain - Neuromodulation (Pre-Clinical)
Second Topic: Emerging Technologies
Objectives:
This study investigates using fiber photometry-based calcium signals to evaluate the neuromodulatory effects of low-intensity focused ultrasound (FUS) on suppressing acute seizures and neuronal excitability.
Methods:
A PTZ-induced acute seizure rat model was used, with GCaMP-labeled neurons in the motor cortex. Real-me intracellular calcium dynamics and ECoG were monitored simultaneously. Low intensity FUS (1.5 MPa) was applied to the seizure onset zone. We analyzed the correla on between calcium surges and ECoG power, evalua ng FUS efficacy in reducing seizure dura on, spike frequency, and calcium wave amplitude through both burst and continuous wave sonications.
Results:
FUS sonication significantly suppressed seizure activity, reducing mean seizure duration by 43% and spike frequency by 51%. Fiber hotometry revealed that FUS effectively inhibited the PTZ induced intracellular calcium surges, with a 48% reduction in GCaMP fluorescence ntensity
compared to the control group. A strong temporal correla on (r^2 = 0.82) was observed between ECoG power bursts and calcium wave peaks. Furthermore, FUS treatment decreased the velocity of spreading calcium waves across the cortex. These findings suggest that calcium dynamics serve as a robust, high-resolu on biomarker for real-time monitoring of FUS-induced neurosuppression.
Conclusions:
Low-intensity FUS effec vely suppresses acute seizures by inhibiting calcium-mediated neuronal excitability and network synchroniza on. Fiber photometry-based calcium imaging provides a reliable, real-time alternative to ECoG for assessing neuromodulation efficacy. This approach offers crucial insights into the cellular mechanisms of FUS, supporting its development as a non-invasive epilepsy therapy.
Acknowledgements:
This work was supported by the National Science and Technology Council of Taiwan.